Izizathu ze-psoriasis ziquka izinto zemfuza, ezomzimba, ezokusingqongileyo kunye nezinye izinto, kwaye i-pathogenesis yayo ayikacaci ngokupheleleyo.
1. Izinto ezibangela ufuzo
Izifundo ezininzi zibonise ukuba izinto zemfuza zidlala indima ebalulekileyo kwi-pathogenesis ye-psoriasis. Imbali yentsapho yesi sifo ibandakanya i-10% ukuya kwi-23.8% yezigulane eTshayina kwaye malunga ne-30% kumazwe angaphandle.Amathuba okuba nomntwana one-psoriasis yi-2% ukuba akukho mzali unesifo, yi-41% ukuba bobabini abazali banesi sifo, kwaye yi-14% ukuba omnye umzali unesi sifo.Izifundo zamawele anxulunyaniswa ne-psoriasis zibonise ukuba amawele e-monozygotic anethuba elingama-72% lokuba nesifo ngaxeshanye kwaye amawele e-dizygotic anethuba elingama-30% lokuba nesifo ngaxeshanye. Kuye kwachongwa iindawo ezingaphezu kwe-10 ezibizwa ngokuba yi-susceptibility loci ezinxulunyaniswa kakhulu nophuhliso lwe-psoriasis.
2. Izinto ezibangela ukungasebenzi kakuhle komzimba
Ukusebenza okungaqhelekanga kwe-T-lymphocytes kunye nokungena kwi-epidermis okanye kwi-dermis ziimpawu ezibalulekileyo ze-psoriasis, nto leyo ebonisa ukubandakanyeka kwenkqubo yomzimba yokuzikhusela ekuphuhlisweni nasekuqhubekeni kwesifo.Izifundo zakutshanje zibonise ukuba ukuveliswa kwe-IL-23 ziiseli ze-dendritic kunye nezinye iiseli ezibonisa i-antigen (ii-APC) kubangela ukwahluka kunye nokwanda kwee-CD4+ helper T lymphocytes, iiseli ze-Th17, kunye neeseli ze-Th17 ezivuthiweyo ezahlukeneyo zinokukhupha iintlobo ngeentlobo zeeseli ezifana ne-Th17 ezifana ne-IL-17, i-IL-21, kunye ne-IL-22, ezikhuthaza ukwanda kakhulu kweeseli ezenza i-keratin okanye impendulo yokuvuvukala kweeseli ze-synovial. Ke ngoko, iiseli ze-Th17 kunye ne-IL-23/IL-17 axis zinokudlala indima ebalulekileyo kwi-pathogenesis ye-psoriasis.
3. Izinto ezichaphazela indalo kunye ne-Metabolic
Izinto ezingqongileyo zidlala indima ebalulekileyo ekubangeleni okanye ekwandiseni i-psoriasis, okanye ekwandiseni ixesha lesi sifo, kubandakanya usulelo, uxinzelelo lwengqondo, imikhwa emibi (umz., ukutshaya, utywala), ukwenzakala, kunye neempendulo kumayeza athile.Ukuqala kwe-pitting psoriasis kudla ngokunxulunyaniswa nosulelo oluqatha lwe-streptococcal kwi-pharynx, kwaye unyango lokulwa nosulelo lunokukhokelela ekuphuculeni nasekunciphiseni okanye ekuphumleni kwezilonda zesikhumba. Uxinzelelo lwengqondo (njengoxinzelelo, iingxaki zokulala, ukusebenza kakhulu) lunokubangela ukuba i-psoriasis ivele, ibe mandundu okanye iphinde ivele, kwaye ukusetyenziswa konyango olucebisa ngengqondo kunokunciphisa imeko. Kukwafunyaniswa ukuba uxinzelelo lwegazi oluphezulu, isifo seswekile, i-hyperlipidemia, isifo semithambo yentliziyo kunye ne-metabolic syndrome zixhaphake kakhulu phakathi kwabaguli be-psoriasis.
Ixesha leposi: Matshi 17-2023
