Ziziphi izizathu ze psoriasis?

Izizathu ze-psoriasis zibandakanya imfuza, i-immune, indalo kunye nezinye izinto, kwaye i-pathogenesis yayo ayikacaci ngokupheleleyo.

 1. Imiba yemfuza

Izifundo ezininzi zibonise ukuba izinto zofuzo zidlala indima ebalulekileyo kwi-pathogenesis ye-psoriasis. Imbali yentsapho yesi sifo ibalelwa kwi-10% ukuya kwi-23.8% yezigulane zaseTshayina kunye ne-30% kumazwe angaphandle.Amathuba okuba nomntwana one-psoriasis yi-2% ukuba akukho mzali unesi sifo, ama-41% ukuba bobabini abazali banesi sifo, kunye ne-14% ukuba umzali omnye unesi sifo.Izifundo zamawele ezinxulumene ne-psoriasis zibonise ukuba amawele e-monozygotic ane-72% amathuba okuba nesifo ngexesha elifanayo kunye namawele e-dizygotic ane-30% yokuba nesifo ngexesha elifanayo. Ngaphezulu kwe-10 ebizwa ngokuba yi-susceptibility loci iye yachongwa ehambelana kakhulu nokuphuhliswa kwe-psoriasis.

2. Imiba yamajoni omzimba

 Ukusebenza okungaqhelekanga kwe-T-lymphocytes kunye nokungena kwi-epidermis okanye kwi-dermis zizinto ezibalulekileyo ze-pathophysiological ze-psoriasis, ezibonisa ukubandakanyeka kwe-immune system ekuphuhliseni nasekuqhubeleni phambili kwesi sifo.Uphononongo lwakutsha nje lubonise ukuba ukuveliswa kwe-IL-23 ngamaseli e-dendritic kunye nezinye iiseli ze-antigen-presenting (APCs) kubangela ukwahlula kunye nokwanda kwe-CD4 + umncedisi we-T lymphocytes, iiseli ze-Th17, kunye neeseli ezivuthiweyo ze-Th17 zinokukhupha izinto ezahlukeneyo zeselula ezifana ne-Th17. njenge-IL-17, IL-21, kunye ne-IL-22, ekhuthaza ukwanda okugqithiseleyo kweeseli ezenza i-keratin okanye impendulo yokuvuvukala kweeseli ze-synovial. Ngoko ke, iiseli ze-Th17 kunye ne-IL-23 / IL-17 i-axis inokudlala indima ebalulekileyo kwi-pathogenesis ye-psoriasis.

3. Imiba yokusiNgqongileyo kunye neMetabolic

Imiba yokusingqongileyo idlala indima ebalulekileyo ekuqaliseni okanye ekukhuliseni i-psoriasis, okanye ekwandiseni isifo, kuquka ukusuleleka, ukuxinezeleka kwengqondo, imikhwa emibi (umzekelo, ukutshaya, ukusela utywala), ukwenzakala, kunye nokusabela kumayeza athile.Ukuqala kwe-pitting psoriasis kudla ngokuhambelana nokusuleleka kwi-streptococcal ye-pharynx, kwaye unyango oluchasayo lunokukhokelela ekuphuculeni kunye nokunciphisa okanye ukuxolelwa kwezilonda zesikhumba. Ukuxinezeleka kwengqondo (okufana noxinzelelo, ukuphazamiseka kokulala, ukusebenza ngokugqithiseleyo) kunokubangela ukuba i-psoriasis yenzeke, ibe mandundu okanye iphinde ibuyele, kunye nokusetyenziswa konyango lweengcebiso zengqondo kunokunciphisa imeko. Kukwafunyaniswa ukuba uxinzelelo lwegazi, isifo sikashukela, i-hyperlipidemia, isifo se-coronary artery kunye ne-syndrome ye-metabolic ixhaphake kakhulu phakathi kwezigulane ze-psoriasis.